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Toll-like receptor initiated host defense against Toxoplasma gondii Denkers EYJ Biomed Biotechnol 2010[]; 2010 (ä): 737125Toxoplasma gondii is an intracellular pathogen notable for its ability to establish a stable host-parasite relationship amongst a wide range of host species and in a large percentage of the human population. Toll-like receptor signaling through MyD88 is a critical pathway in initiating defense against this opportunistic protozoan and may also be a mediator of pathology during immune dysfunction. Other MyD88 independent signaling pathways are also involved in the host-parasite interaction. These responses can be triggered by the parasite itself, but interactions with the intestinal microbiota add additional complexity during enteric infection.|Animals[MESH]|Disease Models, Animal[MESH]|Host-Parasite Interactions/immunology[MESH]|Humans[MESH]|Mice[MESH]|Myeloid Differentiation Factor 88/immunology[MESH]|Signal Transduction/immunology[MESH]|Toll-Like Receptors/*immunology[MESH]|Toxoplasma/*immunology[MESH]|Toxoplasmosis/*immunology[MESH] |
