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Migraine pathogenesis and state of pharmacological treatment options Sprenger T; Goadsby PJBMC Med 2009[Nov]; 7 (�): 71Migraine is a largely inherited disorder of the brain characterized by a complex, but stereotypical, dysfunction of sensory processing. Often the most obvious clinical symptom is head pain, but non-headache symptoms such as photophobia, phonophobia and nausea are clearly part of the typical presentation. This review discusses the current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. Acute and preventive migraine treatment approaches are briefly covered with a focus on shortcomings of the currently available treatment options. A number of different receptors, such as calcitonin gene-related peptide (CGRP), TRPV1 and glutamate receptors, are currently being targeted by potential novel migraine therapeutics. The prospects of this research are exciting and are likely to improve patient care.|Biomedical Research/trends[MESH]|Brain Stem/physiopathology[MESH]|Cerebral Cortex/physiopathology[MESH]|Humans[MESH]|Migraine Disorders/*drug therapy/*physiopathology[MESH] |