Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Drugs that suppress TSH or cause central hypothyroidism Haugen BRBest Pract Res Clin Endocrinol Metab 2009[Dec]; 23 (6): 793-800Many different drugs affect thyroid function. Most of these drugs act at the level of the thyroid in patients with normal thyroid function, or at the level of thyroid hormone absorption or metabolism in patients requiring exogenous levothyroxine. A small subset of medications including glucocorticoids, dopamine agonists, somatostatin analogues and rexinoids affect thyroid function through suppression of TSH in the thyrotrope or hypothalamus. Fortunately, most of these medications do not cause clinically evident central hypothyroidism. A newer class of nuclear hormone receptors agonists, called rexinoids, cause clinically significant central hypothyroidism in most patients and dopamine agonists may exacerbate 'hypothyroidism' in patients with non-thyroidal illness. In this review, we explore mechanisms governing TSH suppression of these drugs and the clinical relevance of these effects.|Aged[MESH]|Bexarotene[MESH]|Dopamine Agonists/pharmacology[MESH]|Glucocorticoids/pharmacology[MESH]|Humans[MESH]|Hypothyroidism/*chemically induced[MESH]|Lymphoma, T-Cell/drug therapy[MESH]|Male[MESH]|Metformin/adverse effects[MESH]|Retinoid X Receptors/drug effects[MESH]|Somatostatin/analogs & derivatives[MESH]|Tetrahydronaphthalenes/adverse effects[MESH]|Thyrotropin/*antagonists & inhibitors/blood[MESH] |
