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An algorithm for managing warfarin resistance Osinbowale O; Al Malki M; Schade A; Bartholomew JRCleve Clin J Med 2009[Dec]; 76 (12): 724-30Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.|*Drug Resistance[MESH]|Algorithms[MESH]|Anticoagulants/administration & dosage/pharmacokinetics/*pharmacology[MESH]|Dose-Response Relationship, Drug[MESH]|Drug Monitoring/*methods[MESH]|Humans[MESH]|Warfarin/administration & dosage/pharmacokinetics/*pharmacology[MESH] |
