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Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors Haslund P; Lee RA; Jemec GBActa Derm Venereol 2009[Nov]; 89 (6): 595-600Hidradenitis suppurativa (HS) is a common inflammatory skin disease. Medical treatment is often disappointing and in severe disease surgery remains the therapy of choice. Extensive surgery may be effective but also mutilating. Patients experience a significant reduction in quality of life and the need for new treatment modalities are urgent. In recent years patients with HS have been treated off-label with tumour necrosis factor-alpha (TNF-alpha) inhibitors with a varying degrees of effect. We performed a systematic review of papers retrieved from two databases (PubMed and Web of Science) using the follow-ing keywords: hidradenitis suppurativa, acne inversa, infliximab, etanercept, and adalimumab. A total of 34 publications were retrieved, describing treatment of 105 patients. Most cases report treatment with infliximab (52/105). A positive treatment outcome was reported in 90/105 cases, with only 7/105 non-responders and 8/105 patients experiencing side-effects. The side-effects were comparable to those seen in other TNF-alpha inhibitor studies. In the majority of cases the treatment was effective when given as a suppressive therapy, but 15/105 cases were described with long-term remission (>or= 3 months) after the end of therapy. In most publications follow-up was, however, insufficient to allow a systematic exploration of this. TNF-alpha inhibitors seem to be effective in the treatment of HS. However, several questions remain to be answered through specific studies. This review has also identified a need for more standardized reporting of the outcomes as well as randomized controlled trials in this disease.|Adalimumab[MESH]|Antibodies, Monoclonal, Humanized[MESH]|Antibodies, Monoclonal/therapeutic use[MESH]|Dermatologic Agents/*therapeutic use[MESH]|Dose-Response Relationship, Drug[MESH]|Etanercept[MESH]|Hidradenitis Suppurativa/*drug therapy[MESH]|Humans[MESH]|Immunoglobulin G/therapeutic use[MESH]|Infliximab[MESH]|Receptors, Tumor Necrosis Factor/therapeutic use[MESH]|Tumor Necrosis Factor-alpha/*antagonists & inhibitors[MESH] |
