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Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence Morales AM; Mirone V; Dean J; Costa PClin Interv Aging 2009[]; 4 (ä): 463-72Many men with erectile dysfunction (ED) also have associated underlying cardiovascular and metabolic conditions, for which they are likely to be taking medication. Therefore, cardiovascular safety and potential drug interactions are two of the major concerns when using PDE-5 inhibitors in these patients. The PDE-5 inhibitor, vardenafil, is characterized by a rapid onset of action, increased duration of erection, high rates of first-dose success and reliable efficacy that can be maintained with continued use. In both clinical trials and real-life observational studies, vardenafil has demonstrated a favorable efficacy and safety profile in men with ED, including those with associated underlying conditions such as diabetes, hypertension and dyslipidemia. Importantly, the concomitant use of medication for these conditions is not associated with any noteworthy changes in the efficacy and safety of vardenafil. The evidence presented in this review supports the use of vardenafil as a first-line treatment for men with ED, including those with underlying conditions.|Aging[MESH]|Cardiovascular Diseases/complications[MESH]|Clinical Trials as Topic[MESH]|Diabetes Complications[MESH]|Drug Interactions[MESH]|Erectile Dysfunction/complications/*drug therapy/*epidemiology[MESH]|Humans[MESH]|Imidazoles/adverse effects/*therapeutic use[MESH]|Male[MESH]|Metabolic Syndrome/complications[MESH]|Phosphodiesterase Inhibitors/adverse effects/*therapeutic use[MESH]|Piperazines/adverse effects/*therapeutic use[MESH]|Prevalence[MESH]|Risk Factors[MESH]|Sulfones/adverse effects/therapeutic use[MESH]|Triazines/adverse effects/therapeutic use[MESH]|Vardenafil Dihydrochloride[MESH] |
