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Motavizumab Cingoz OMAbs 2009[Sep]; 1 (5): 439-42Motavizumab (MEDI-524, Numax) is a second generation monoclonal antibody (mAb) derived from palivizumab (Synagis) using affinity maturation techniques. Motavizumab is currently undergoing US Food and Drug Administration review as a treatment for respiratory syncytial virus (RSV) prophylaxis. It has been evaluated in large-scale clinical studies, and has demonstrated efficacy in reducing the disease burden of RSV in high-risk infant populations.|*Antibodies, Monoclonal/administration & dosage/adverse effects/immunology/therapeutic use[MESH]|Antibodies, Monoclonal, Humanized[MESH]|Child, Preschool[MESH]|Clinical Trials as Topic[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Respiratory Syncytial Virus Infections/*drug therapy/immunology/*prevention & control[MESH]|Respiratory Syncytial Virus, Human/*immunology[MESH]|Treatment Outcome[MESH] |
