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Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement Schreml S; Szeimies RM; Vogt T; Landthaler M; Schroeder J; Babilas PEur J Dermatol 2010[Mar]; 20 (2): 152-60Extracellular deposition of altered autologous protein (amyloid protein) within the dermis is the hallmark of cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement. Amyloidoses may be acquired or hereditary in nature and subclassification differentiates between primary amyloidosis (no obvious predisposing disease) and secondary amyloidosis (specific underlying disease). More than 26 different proteins and peptides have been identified as amyloid precursors and these proteins are used to subclassify this heterogeneous group of diseases. The amyloid proteins show an anti-parallel beta-sheet conformation and form non-branching linear filaments of variable lengths and diameters of approximately 7.5 to 10 nm. However, the exact etiopathogenesis of amyloid formation still remains unclear. Depending on histoanatomical distribution and amount, amyloid may cause progressive and life-threatening organ dysfunction. Clinical presentation, histology, electron microscopy, and biochemical-immunological differentiation represent decisive tools for an accurate diagnosis.|Adrenal Cortex Hormones/therapeutic use[MESH]|Amyloid/analysis[MESH]|Amyloidosis/classification/*diagnosis/genetics/therapy[MESH]|Dermatologic Agents/therapeutic use[MESH]|Humans[MESH]|Patient Care Team[MESH]|Racial Groups[MESH]|Skin Diseases, Genetic/classification/*diagnosis/therapy[MESH]|Skin Diseases, Metabolic/classification/*diagnosis/therapy[MESH]|Skin/pathology[MESH] |