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Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection Tan JJ; Cong XJ; Hu LM; Wang CX; Jia L; Liang XJDrug Discov Today 2010[Mar]; 15 (5-6): 186-97The HIV replication cycle offers multiple targets for chemotherapeutic intervention, including the viral exterior envelope glycoprotein, gp120; viral co-receptors CXCR4 and CCR5; transmembrane glycoprotein, gp41; integrase; reverse transcriptase; protease and so on. Most currently used anti-HIV drugs are reverse transcriptase inhibitors or protease inhibitors. The expanding application of simulation to drug design combined with experimental techniques have developed a large amount of novel inhibitors that interact specifically with targets besides transcriptase and protease. This review presents details of the anti-HIV inhibitors discovered with computer-aided approaches and provides an overview of the recent five-year achievements in the treatment of HIV infection and the application of computational methods to current drug design.|Animals[MESH]|Anti-HIV Agents/chemical synthesis/*therapeutic use[MESH]|Disease Management[MESH]|Drug Discovery/*methods/trends[MESH]|HIV Infections/*drug therapy/immunology[MESH]|Humans[MESH] |
