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Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases Aquilina K; Merchant TE; Rodriguez-Galindo C; Ellison DW; Sanford RA; Boop FAJ Neurosurg Pediatr 2010[Feb]; 5 (2): 155-61Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.|Carcinoma, Squamous Cell/pathology/surgery[MESH]|Cell Transformation, Neoplastic/*radiation effects[MESH]|Child[MESH]|Child, Preschool[MESH]|Combined Modality Therapy[MESH]|Craniopharyngioma/*pathology/*radiotherapy/surgery[MESH]|Female[MESH]|Fibrosis[MESH]|Humans[MESH]|Keratinocytes/pathology[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Meninges/pathology[MESH]|Neurosurgical Procedures[MESH]|Pituitary Neoplasms/*pathology/*radiotherapy/surgery[MESH]|Radiotherapy/*adverse effects[MESH]|Risk Assessment[MESH] |
