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Molecular approach to human leukemia: isolation and characterization of the first human retrovirus HTLV-1 and its impact on tumorigenesis in adult T-cell leukemia Yoshida MProc Jpn Acad Ser B Phys Biol Sci 2010[]; 86 (2): 117-30Molecular biology of mouse and chicken retroviruses had identified oncogenes and provided a revolutionary concept in understanding of cancers. A human retrovirus was established during 1980-1982 in linkage with a unique human leukemia, concurrently in Japan and USA. This review covers our efforts on the discovery of new retrovirus, Human T-cell Leukemia Virus Type 1 (HTLV-1), first introducing to a new class of retroviruses with a unique regulatory factors, Tax and Rex. Then it is followed by analyses of molecular interaction of the vial Tax with cellular machineries involved in the pathogenesis of Adult T-cell Leukemia (ATL). And then a probable mechanism of pathogenesis of ATL is proposed including recent findings on HBZ after our efforts.|Adult[MESH]|Human T-lymphotropic virus 1/*isolation & purification/*pathogenicity/physiology[MESH]|Humans[MESH]|Leukemia-Lymphoma, Adult T-Cell/genetics/*pathology/*virology[MESH]|Virus Replication[MESH] |