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Gene therapy for mesothelioma and lung cancer Vachani A; Moon E; Wakeam E; Albelda SMAm J Respir Cell Mol Biol 2010[Apr]; 42 (4): 385-93Both malignant pleural mesothelioma and advanced stage lung cancer are associated with a poor prognosis. Unfortunately, current treatment regimens have had only a modest effect on their progressive course. Gene therapy for thoracic malignancies represents a novel therapeutic approach and has been evaluated in a number of clinical trials over the last two decades. Using viral vectors or anti-sense RNA, strategies have included induction of apoptosis, tumor suppressor gene replacement, suicide gene expression, cytokine-based therapy, various vaccination approaches, and adoptive transfer of modified immune cells. This review will consider the clinical results, limitations, and future directions of gene therapy trials for thoracic malignancies.|Adoptive Transfer/methods[MESH]|Animals[MESH]|Apoptosis/genetics/immunology[MESH]|Cancer Vaccines/genetics/immunology/therapeutic use[MESH]|Clinical Trials as Topic[MESH]|Cytokines/genetics/immunology[MESH]|Genes, Transgenic, Suicide/genetics/immunology[MESH]|Genes, Tumor Suppressor[MESH]|Genetic Therapy/*methods[MESH]|Genetic Vectors/genetics/immunology[MESH]|Humans[MESH]|Lung Neoplasms/diagnosis/genetics/immunology/*therapy[MESH]|Mesothelioma/diagnosis/genetics/immunology/*therapy[MESH]|Pleural Neoplasms/diagnosis/genetics/immunology/*therapy[MESH]|Prognosis[MESH]|RNA, Antisense/genetics/immunology[MESH]|Viruses/genetics[MESH] |
