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Cytoskeletal mechanisms for breaking cellular symmetry Mullins RDCold Spring Harb Perspect Biol 2010[Jan]; 2 (1): a003392Cytoskeletal systems are networks of polymers found in all eukaryotic and many prokaryotic cells. Their purpose is to transmit and integrate information across cellular dimensions and help turn a disorderly mob of macromolecules into a spatially organized, living cell. Information, in this context, includes physical and chemical properties relevant to cellular physiology, including: the number and activity of macromolecules, cell shape, and mechanical force. Most animal cells are 10-50 microns in diameter, whereas the macromolecules that comprise them are 10,000-fold smaller (2-20 nm). To establish long-range order over cellular length scales, individual molecules must, therefore, self-assemble into larger polymers, with lengths (0.1-20 m) comparable to the size of a cell. These polymers must then be cross-linked into organized networks that fill the cytoplasm. Such cell-spanning polymer networks enable different parts of the cytoplasm to communicate directly with each other, either by transmitting forces or by carrying cargo from one spot to another.|Animals[MESH]|Cytoskeleton/*metabolism[MESH]|Humans[MESH]|Macromolecular Substances/metabolism[MESH]|Microtubules/metabolism[MESH]|Models, Biological[MESH]|Oocytes/metabolism[MESH]|Polymers/chemistry[MESH]|Spindle Apparatus/metabolism[MESH] |
