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Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?Neumann D; Beermann S; Seifert RPharmacology 2010[]; 85 (4): 217-23The histamine H4 receptor is expressed preferentially on immune cells, indicating a possible role of the H4 receptor in inflammation. Studies of inflammation in several animal models point to a pro-inflammatory function of the H4 receptor. However, studies on experimental murine bronchial asthma yielded conflicting results, a fact which is neglected in most H4 receptor publications. Therefore, the present review critically analyzes available data on the role of the H4 receptor in the murine bronchial asthma model.|Animals[MESH]|Asthma/*physiopathology[MESH]|Disease Models, Animal[MESH]|Histamine/physiology[MESH]|Humans[MESH]|Indoles/pharmacology[MESH]|Inflammation/physiopathology[MESH]|Mice[MESH]|Piperazines/pharmacology[MESH]|Receptors, G-Protein-Coupled/drug effects/*physiology[MESH]|Receptors, Histamine H3/physiology[MESH]|Receptors, Histamine H4[MESH]|Receptors, Histamine/drug effects/*physiology[MESH] |
