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IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model Kim JH; Song HY; Park JH; Yoon HJ; Park HG; Kim DKRadiology 2010[Apr]; 255 (1): 75-82PURPOSE: To evaluate the efficacy of an activin receptor-like kinase-5 inhibitor, IN-1233, for the prevention of tissue hyperplasia after bare stent placement in a rat urethral model. MATERIALS AND METHODS: Procedures were performed in accordance with the National Institutes of Health guidelines for humane handling of animals; approval of the committee of animal research was obtained. In 20 Sprague-Dawley male rats (weight range, 300-350 g), a self-expanding metallic bare stent was inserted in the urethra by using fluoroscopic guidance. One group of 10 rats (group A) was treated with IN-1233, the other group of 10 rats (group B) received no treatment. Retrograde urethrography was performed 4 and 8 weeks after stent placement. All rats were sacrificed at 8 weeks for histologic analysis. RESULTS: Stent placement was technically successful in all rats. The average stent diameter was significantly larger in group A compared with group B at follow-up retrograde urethrography performed 4 (P = .006) and 8 (P < .001) weeks after stent placement. At histologic analysis, the percentage of granulation tissue area (P < .001), thickness of submucosal fibrosis (P < .001), and number of epithelial layers (P < .001) were significantly decreased in group A compared with group B. Inflammatory cell infiltration (P < .001) was significantly increased in group A compared with group B. CONCLUSION: IN-1233 is effective for the prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model.|*Stents/adverse effects[MESH]|Animals[MESH]|Benzamides/*pharmacology[MESH]|Granulation Tissue/diagnostic imaging/*drug effects/*pathology[MESH]|Hyperplasia[MESH]|Male[MESH]|Metals[MESH]|Quinolines/*pharmacology[MESH]|Radiography[MESH]|Rats[MESH]|Rats, Sprague-Dawley[MESH]|Statistics, Nonparametric[MESH]|Urethra/diagnostic imaging/*drug effects/*pathology[MESH] |
