Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation Shah S; Nonnemacher MR; Pirrone V; Wigdahl BJ Neuroimmune Pharmacol 2010[Sep]; 5 (3): 278-93Over the past decade, antiretroviral therapy targeting the viral entry process, reverse transcriptase, integrase, and protease, has prolonged the lives of people infected with human immunodeficiency virus type 1 (HIV-1). However, despite the development of more effective therapeutic strategies, reservoirs of viral infection remain. This review discusses molecular mechanisms surrounding the development of latency from the site of integration to pre- and post-integration maintenance of latency, including epigenetic factors. In addition, an overview of innate and adaptive cells important to HIV-1 infection are examined from the viewpoint of cytokines released and cytokines that act on these cells to explore an overall understanding of HIV-1 proviral genome activation. Finally, this review is discussed from the viewpoint of how an understanding of the interplay of all of these factors will help guide the next generation of therapies.|Anti-HIV Agents/therapeutic use[MESH]|CD4-Positive T-Lymphocytes/immunology[MESH]|Cytokines[MESH]|Epigenesis, Genetic/physiology[MESH]|HIV Infections/drug therapy/immunology/virology[MESH]|HIV Long Terminal Repeat/physiology[MESH]|HIV-1/genetics/immunology/*physiology[MESH]|Humans[MESH]|Immunity, Innate/immunology[MESH]|Virus Activation/drug effects/genetics/physiology[MESH]|Virus Integration/drug effects/physiology[MESH]|Virus Latency/immunology/physiology[MESH] |
