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Memory T-cell trafficking: new directions for busy commuters Marelli-Berg FM; Fu H; Vianello F; Tokoyoda K; Hamann AImmunology 2010[Jun]; 130 (2): 158-65The immune system is unique in representing a network of interacting cells of enormous complexity and yet being based on single cells travelling around the body. The development of effective and regulated immunity relies upon co-ordinated migration of each cellular component, which is regulated by diverse signals provided by the tissue. Co-ordinated migration is particularly relevant to the recirculation of primed T cells, which, while performing continuous immune surveillance, need to promptly localize to antigenic sites, reside for a time sufficient to carry out their effector function and then efficiently leave the tissue to avoid bystander damage. Recent advances that have helped to clarify a number of key molecular mechanisms underlying the complexity and efficiency of memory T-cell trafficking, including antigen-dependent T-cell trafficking, the regulation of T-cell motility by costimulatory molecules, T-cell migration out of target tissue and fugetaxis, are reviewed in this article.|Animals[MESH]|Cell Movement/*physiology[MESH]|Humans[MESH]|Immunologic Memory/*physiology[MESH]|Immunologic Surveillance/*physiology[MESH]|T-Lymphocytes/*immunology[MESH] |
