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Radioprotectors and mitigators of radiation-induced normal tissue injury Citrin D; Cotrim AP; Hyodo F; Baum BJ; Krishna MC; Mitchell JBOncologist 2010[]; 15 (4): 360-71Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compounds are often antioxidants and must be present before or at the time of radiation for effectiveness. Other agents, termed mitigators, may be used to minimize toxicity even after radiation has been delivered. Herein, we review agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury. Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing.|*Radiation Protection[MESH]|*Radiation-Protective Agents[MESH]|Amifostine/therapeutic use[MESH]|Animals[MESH]|Antioxidants/therapeutic use[MESH]|Cyclic N-Oxides/therapeutic use[MESH]|DNA Damage/radiation effects[MESH]|Fibroblast Growth Factor 7/therapeutic use[MESH]|Free Radical Scavengers/therapeutic use[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Neoplasms/*radiotherapy[MESH]|Radiation Injuries/*prevention & control[MESH]|Risk Factors[MESH]|Spin Labels[MESH] |
