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High-dose vs low-dose proton pump inhibitors for upper gastrointestinal bleeding: a meta-analysis Wu LC; Cao YF; Huang JH; Liao C; Gao FWorld J Gastroenterol 2010[May]; 16 (20): 2558-65AIM: To evaluate the efficacy of high-dose proton pump inhibitors (PPIs) vs low-dose PPIs for patients with upper gastrointestinal bleeding. METHODS: PubMed, Embase, the Cochrane Library, and Web of Science were searched to identify relevant randomized controlled trials (RCTs). Eligible trials were RCTs that compared high-dose PPI with low-dose PPI following endoscopic hemostasis. The primary endpoint was rebleeding; secondary endpoints were patient numbers that needed surgery, and mortality. The meta-analysis was performed with a fixed effects model or random effects model. RESULTS: Nine eligible RCTs including 1342 patients were retrieved. The results showed that high-dose intravenous PPI was not superior to low-dose intravenous PPI in reducing rebleeding [odds ratio (OR) = 1.091, 95% confidential interval (CI): 0.777-1.532], need for surgery (OR = 1.522, 95% CI: 0.643-3.605) and mortality (OR = 1.022, 95% CI: 0.476-2.196). Subgroup analysis according to different region revealed no difference in rebleeding rate between Asian patients (OR = 0.831, 95% CI, 0.467-1.480) and European patients (OR = 1.263, 95% CI: 0.827-1.929). CONCLUSION: Low-dose intravenous PPI can achieve the same efficacy as high-dose PPI following endoscopic hemostasis.|Databases, Factual[MESH]|Dose-Response Relationship, Drug[MESH]|Gastrointestinal Hemorrhage/*drug therapy/mortality/prevention & control/surgery[MESH]|Hemostasis, Endoscopic[MESH]|Humans[MESH]|Proton Pump Inhibitors/*therapeutic use[MESH]|Randomized Controlled Trials as Topic[MESH]|Recurrence[MESH]|Upper Gastrointestinal Tract/*pathology/surgery[MESH] |
