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Calcium signaling through CatSper channels in mammalian fertilization Ren D; Xia JPhysiology (Bethesda) 2010[Jun]; 25 (3): 165-75The molecular mechanisms underlying Ca(2+) entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought.|Animals[MESH]|Calcium Channels/genetics/*physiology[MESH]|Calcium Signaling/*physiology[MESH]|Fertilization/*physiology[MESH]|Male[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Models, Animal[MESH]|Sperm Motility/physiology[MESH] |
