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The giant protein titin as an integrator of myocyte signaling pathways Linke WA; Kruger MPhysiology (Bethesda) 2010[Jun]; 25 (3): 186-98The giant muscle protein titin, the "backbone" of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease. Titin is increasingly recognized as a crucial integrator of diverse myocyte signaling pathways. The titin-associated signalosome includes hotspots of protein-protein interactions important for the regulation of protein quality-control mechanisms, hypertrophic gene activation, and mechanosensing.|Animals[MESH]|Collagen/physiology[MESH]|Connectin[MESH]|Elasticity/physiology[MESH]|Humans[MESH]|Muscle Fibers, Skeletal/*physiology[MESH]|Muscle Proteins/*physiology[MESH]|Muscle, Skeletal/physiology[MESH]|Protein Kinases/*physiology[MESH]|Signal Transduction/*physiology[MESH] |
