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Shielding in whole brain irradiation in the multileaf collimator era: dosimetric evaluation of coverage using SFOP guidelines against in-house guidelines Patil VM; Oinam AS; Chakraborty S; Ghoshal S; Sharma SCJ Cancer Res Ther 2010[Apr]; 6 (2): 152-8AIM: Compare the planning target volume (PTV) coverage in three different shielding techniques in cranial irradiation. SETTINGS AND DESIGN: Tertiary care center, prospective study. MATERIALS AND METHODS: The whole brain and meninges were contoured in ten planning CT scans, and expanded by 5 mm for the PTV. Shielding was designed using the French Society of Pediatric Oncology (SFOP) guidelines (SFOP plan), in-house recommendation (with 1 cm margin from the orbital roof and sphenoid wing) on a igitally Reconstructed Radiograph (DRR) and a third plan was generated using a 3D conformal radiation technique (3DCRT). The coverage of the PTV was noted using the isodose covering 95% of the PTV(D95), minimum dose within the PTV(D min ), and maximum dose within the PTV(D max ). The location of PTV not covered by the 95% isodose curve was noted. The median dose and maximum dose (D max ) to both eyes and maximum dose D max for the lens were noted. STATISTICAL ANALYSIS: General linear model method repeated the measure of analysis of variance test (ANOVA). RESULTS: PTV coverage was significantly poorer in the SFOP and in-house plans as compared to 3DCRT plan (P=0.04). Median volume of PTV not covered by 95% isodose curve was 4.18 cc, 1.01 cc, and 0 cc in SFOP, in-house, and 3DCRT plan, respectively. CONCLUSIONS: In the absence of volumetric planning techniques, SFOP guidelines lead to inadequate coverage and the in-house method is recommended.|*Cranial Irradiation[MESH]|*Radiotherapy Planning, Computer-Assisted[MESH]|Brain Neoplasms/*radiotherapy[MESH]|Humans[MESH]|Medical Oncology/standards[MESH]|Pediatrics/standards[MESH]|Practice Guidelines as Topic/*standards[MESH]|Prospective Studies[MESH]|Radiation Protection/*instrumentation[MESH]|Radiotherapy Dosage[MESH]|Radiotherapy, Conformal[MESH] |
