Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Focal oxidant and Ras signaling on the ER surface activates autophagy Wu RF; Terada LSAutophagy 2010[Aug]; 6 (6): 828-9Eukaryotic cells react to a variety of intrinsic and extrinsic stresses with patterned responses, each triggered within relevant subcellular domains. One feature common to a variety of cellular stresses is the production of reactive oxidant species (ROS), suggesting an additional element of oxidative stress. We addressed the role of oxidants in ER stress and find instead that localized production of ROS by the ER mediates protective signaling, leading to, among other things, Ras-dependent activation of autophagy. Thus, focal oxidant production is incorporated into stress response pathways, in this case participating in homeostatic signaling circuits on the ER surface.|*Autophagy[MESH]|*Signal Transduction[MESH]|Endoplasmic Reticulum/*enzymology[MESH]|Enzyme Activation[MESH]|Intracellular Membranes/metabolism[MESH]|Oxidants/*metabolism[MESH]|Reactive Oxygen Species/metabolism[MESH]|Schizosaccharomyces/metabolism[MESH]|Surface Properties[MESH]|ras Proteins/*metabolism[MESH] |
