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Pleiotropic effects of transforming growth factor-beta in hematopoietic stem-cell transplantation Coomes SM; Moore BBTransplantation 2010[Dec]; 90 (11): 1139-44Transforming growth factor (TGF)-beta is a pleiotropic cytokine with beneficial and detrimental effects posthematopoietic stem-cell transplantation. TGF-beta is increased in specific sites postengraftment and can suppress immune responses and maintain peripheral tolerance. Thus, TGF-beta may promote allograft acceptance. However, TGF-beta is also the central pathogenic cytokine in fibrotic disease and likely promotes pneumonitis. Although TGF-beta can enhance leukocyte recruitment and IgA production, it inhibits both innate and adaptive immune cell function and antiviral host defense posthematopoietic stem-cell transplantation. This review will focus on the current understanding of TGF-beta biology and the numerous ways it can impact outcomes posttransplant.|*Hematopoietic Stem Cell Transplantation/adverse effects[MESH]|Animals[MESH]|Cell Survival[MESH]|Graft Rejection/immunology[MESH]|Graft Survival[MESH]|Graft vs Host Disease/immunology[MESH]|Hematopoietic Stem Cells/*immunology[MESH]|Humans[MESH]|Pulmonary Fibrosis/immunology[MESH]|T-Lymphocytes, Regulatory/immunology[MESH]|Time Factors[MESH]|Transforming Growth Factor beta/*immunology[MESH]|Transplantation Tolerance[MESH]|Transplantation, Homologous[MESH]|Treatment Outcome[MESH] |
