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Development of antibody surrogates for the treatment of cancers and autoimmune disease Kodadek TCurr Opin Chem Biol 2010[Dec]; 14 (6): 721-7Some therapeutic monoclonal antibodies function by focusing the killing power of the immune system on particular cellular targets, a process known as antibody-dependent cell-mediated cytotoxicity (ADCC). There is considerable interest in developing small-molecule therapeutics that utilize this mechanism of action and so act as a kind of antibody surrogate. Progress and challenges in this interesting field are reviewed here.|Animals[MESH]|Antibodies/*immunology/therapeutic use[MESH]|Autoimmune Diseases/drug therapy/*immunology[MESH]|Biomimetic Materials/chemistry[MESH]|Humans[MESH]|Ligands[MESH]|Neoplasms/drug therapy/*immunology[MESH] |
