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Clostridium difficile infection Heinlen L; Ballard JDAm J Med Sci 2010[Sep]; 340 (3): 247-52Clostridium difficile is the leading cause of hospital-acquired diarrhea in Europe and North America and is a serious reemerging pathogen. Recent outbreaks have led to increasing morbidity and mortality and have been associated with a new strain (BI/NAP1/027) of C difficile that produces more toxin than historic strains. With the increasing incidence of C difficile infection, clinicians have also seen a change in the epidemiology with increased infections in previously low-risk populations. This chapter highlights the current knowledge on C difficile virulence, human disease, epidemic outbreaks and optimal treatment strategies.|Clostridioides difficile/*isolation & purification[MESH]|Clostridium Infections/diagnosis/*epidemiology/etiology/microbiology[MESH]|Humans[MESH]|Incidence[MESH] |
