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English Wikipedia
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Gastroesophageal reflux disease: From pathophysiology to treatment Herbella FA; Patti MGWorld J Gastroenterol 2010[Aug]; 16 (30): 3745-9This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett's esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.|Adenocarcinoma/etiology/physiopathology/therapy[MESH]|Barrett Esophagus/etiology/physiopathology/therapy[MESH]|Esophageal Neoplasms/etiology/physiopathology/therapy[MESH]|Esophageal Sphincter, Lower/*physiopathology[MESH]|Esophagitis/etiology/physiopathology/therapy[MESH]|Gastroesophageal Reflux/etiology/*physiopathology/*therapy[MESH]|Helicobacter Infections/microbiology[MESH]|Helicobacter pylori/pathogenicity[MESH]|Hernia, Hiatal/complications[MESH]|Humans[MESH]|Precancerous Conditions/etiology/physiopathology/therapy[MESH]|Risk Factors[MESH]|Treatment Outcome[MESH] |
