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Describing the mechanism of antimicrobial peptide action with the interfacial activity model Wimley WCACS Chem Biol 2010[Oct]; 5 (10): 905-17Antimicrobial peptides (AMPs) have been studied for three decades, and yet a molecular understanding of their mechanism of action is still lacking. Here we summarize current knowledge for both synthetic vesicle experiments and microbe experiments, with a focus on comparisons between the two. Microbial experiments are done at peptide to lipid ratios that are at least 4 orders of magnitude higher than vesicle-based experiments. To close the gap between the two concentration regimes, we propose an "interfacial activity model", which is based on an experimentally testable molecular image of AMP-membrane interactions. The interfacial activity model may be useful in driving engineering and design of novel AMPs.|Amino Acid Sequence[MESH]|Animals[MESH]|Anti-Infective Agents/*chemistry/*pharmacology[MESH]|Antimicrobial Cationic Peptides/*chemistry/*pharmacology[MESH]|Bacteria/*drug effects[MESH]|Bacterial Infections/drug therapy[MESH]|Cell Membrane/*drug effects[MESH]|Humans[MESH]|Membranes, Artificial[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH] |
