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Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans Marakalala MJ; Kerrigan AM; Brown GDMamm Genome 2011[Feb]; 22 (1-2): 55-65The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.|*Polymorphism, Genetic[MESH]|Animals[MESH]|Fungi/*immunology/physiology[MESH]|Humans[MESH]|Lectins, C-Type[MESH]|Membrane Proteins/*genetics/*immunology[MESH]|Mycoses/genetics/*immunology/*microbiology[MESH]|Nerve Tissue Proteins/*genetics/*immunology[MESH] |
