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Archaeal/eukaryal RNase P: subunits, functions and RNA diversification Jarrous N; Gopalan VNucleic Acids Res 2010[Dec]; 38 (22): 7885-94RNase P, a catalytic ribonucleoprotein (RNP), is best known for its role in precursor tRNA processing. Recent discoveries have revealed that eukaryal RNase P is also required for transcription and processing of select non-coding RNAs, thus enmeshing RNase P in an intricate network of machineries required for gene expression. Moreover, the RNase P RNA seems to have been subject to gene duplication, selection and divergence to generate two new catalytic RNPs, RNase MRP and MRP-TERT, which perform novel functions encompassing cell cycle control and stem cell biology. We present new evidence and perspectives on the functional diversification of the RNase P RNA to highlight it as a paradigm for the evolutionary plasticity that underlies the extant broad repertoire of catalytic and unexpected regulatory roles played by RNA-driven RNPs.|Archaea/*enzymology[MESH]|Archaeal Proteins/genetics/metabolism/physiology[MESH]|Bacteria/enzymology[MESH]|Chromatin/metabolism[MESH]|Endoribonucleases/physiology[MESH]|Eukaryota/enzymology[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|Protein Subunits/physiology[MESH]|RNA, Catalytic/genetics[MESH]|Ribonuclease P/genetics/metabolism/*physiology[MESH] |
