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Polihexanide: a safe and highly effective biocide Kaehn KSkin Pharmacol Physiol 2010[]; 23 Suppl (ä): 7-16Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains. Thus, polihexanide is particularly suitable and useful in the struggle against multidrug-resistant bacteria. The ecological database is still incomplete. There is some evidence that biodegradation requires adsorption to inert surfaces and that only a small number of bacterial species are capable of utilizing polihexanide.|*Anti-Infective Agents, Local/adverse effects/chemistry/pharmacology[MESH]|*Biguanides/adverse effects/chemistry/pharmacology[MESH]|*Biofilms[MESH]|*Pseudomonas aeruginosa/drug effects[MESH]|*Staphylococcus aureus/drug effects[MESH]|Animals[MESH]|Anti-Bacterial Agents/pharmacology[MESH]|Bacteria/drug effects[MESH]|Disinfectants/pharmacology[MESH]|Drug Delivery Systems[MESH]|Drug Resistance, Microbial[MESH]|Drug Resistance, Multiple[MESH]|Humans[MESH]|Skin[MESH]|Wound Infection/drug therapy/prevention & control[MESH] |
