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p53 connects tumorigenesis and reprogramming to pluripotency Tapia N; Scholer HRJ Exp Med 2010[Sep]; 207 (10): 2045-8The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.|*Tumor Suppressor Protein p53/genetics/metabolism[MESH]|Animals[MESH]|Cell Dedifferentiation[MESH]|Cell Differentiation[MESH]|Cell Transformation, Neoplastic/*genetics[MESH]|Cellular Reprogramming/*genetics[MESH]|Humans[MESH]|Induced Pluripotent Stem Cells/pathology/*physiology[MESH]|Neoplasms/genetics/pathology[MESH] |
