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lüll The introduction of a diagnostic decision support system (DXplain) into the workflow of a teaching hospital service can decrease the cost of service for diagnostically challenging Diagnostic Related Groups (DRGs) Elkin PL; Liebow M; Bauer BA; Chaliki S; Wahner-Roedler D; Bundrick J; Lee M; Brown SH; Froehling D; Bailey K; Famiglietti K; Kim R; Hoffer E; Feldman M; Barnett GOInt J Med Inform 2010[Nov]; 79 (11): 772-7BACKGROUND: In an era of short inpatient stays, residents may overlook relevant elements of the differential diagnosis as they try to evaluate and treat patients. However, if a resident's first principal diagnosis is wrong, the patient's appropriate evaluation and treatment may take longer, cost more, and lead to worse outcomes. A diagnostic decision support system may lead to the generation of a broader differential diagnosis that more often includes the correct diagnosis, permitting a shorter, more effective, and less costly hospital stay. METHODS: We provided residents on General Medicine services access to DXplain, an established computer-based diagnostic decision support system, for 6 months. We compared charges and cost of service for diagnostically challenging cases seen during the fourth through sixth month of access to DXplain (intervention period) to control cases seen in the 6 months before the system was made available. RESULTS: 564 cases were identified as diagnostically challenging by our criteria during the intervention period along with 1173 cases during the control period. Total charges were $1281 lower (p=.006), Medicare Part A charges $1032 lower (p=0.006) and cost of service $990 lower (p=0.001) per admission in the intervention cases than in control cases. CONCLUSIONS: Using DXplain on all diagnostically challenging cases might save our medical center over $2,000,000 a year on the General Medicine Services alone. Using clinical diagnostic decision support systems may improve quality and decrease cost substantially at teaching hospitals.|*Workflow[MESH]|Cost-Benefit Analysis[MESH]|Decision Support Systems, Clinical/*economics[MESH]|Diagnosis, Computer-Assisted/*economics[MESH]|Diagnosis-Related Groups/*economics[MESH]|Hospitals, Teaching/*economics[MESH]|Humans[MESH] |