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From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation Hosoya T; Maillard I; Engel JDImmunol Rev 2010[Nov]; 238 (1): 110-25GATA family transcription factors play multiple vital roles in hematopoiesis in many cell lineages, and in particular, T cells require GATA-3 for execution of several developmental steps. Transcriptional activation of the Gata3 gene is observed throughout T-cell development and differentiation in a stage-specific fashion. GATA-3 has been described as a master regulator of T-helper 2 (Th2) cell differentiation in mature CD4(+) T cells. During T-cell development in the thymus, its roles in the CD4 versus CD8 lineage choice and at the beta-selection checkpoint are the best characterized. In contrast, its importance prior to beta-selection has been obscured both by the developmental heterogeneity of double negative (DN) 1 thymocytes and the paucity of early T-lineage progenitors (ETPs), a subpopulation of DN1 cells that contains the most immature thymic progenitors that retain potent T-lineage developmental potential. By examining multiple lines of in vivo evidence procured through the analysis of Gata3 mutant mice, we have recently demonstrated that GATA-3 is additionally required at the earliest stage of thymopoiesis for the development of the ETP population. Here, we review the characterized functions of GATA-3 at each stage of T-cell development and discuss hypothetical molecular pathways that mediate these functions.|*Gene Expression Regulation, Developmental/immunology[MESH]|Animals[MESH]|Cell Differentiation/immunology[MESH]|Cell Lineage[MESH]|GATA3 Transcription Factor/genetics/*immunology[MESH]|Humans[MESH]|Mice[MESH]|Mice, Mutant Strains[MESH]|Models, Immunological[MESH]|T-Lymphocyte Subsets/*immunology[MESH]|Th2 Cells/*immunology[MESH]|Thymus Gland/embryology/growth & development/*immunology[MESH] |
