Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Anti-VEGF therapy in breast and lung mouse models of cancers Di Domenico M; Ricciardi C; Fusco A; Pierantoni GMJ Biomed Biotechnol 2011[]; 2011 (ä): 947928Cancer is the second leading cause of death in the world after cardiovascular diseases. Some types of cancer cells often travel to other parts of the body through blood circulation or lymph vessels, where they begin to grow. This process is recognized as metastasis. Angiogenesis is the formation of new blood vessels from existing vessel. Normally angiogenesis is a healthy process, that helps the body to heal wounds and repair damaged body tissues, whereas in cancerous condition this process supports new blood vessels formation that provide a tumor with its own blood supply, nutrients and allow it to grow. The most important proximal factor for angiogenesis is the vascular endothelial growth factor VEGF. Angioinhibition is a form of targeted therapy that uses drugs to stop tumors from making new blood vessels. Therefore, in this paper we analyse the importance of VEGF as target of cancer therapy, analysing murine models.|Animals[MESH]|Disease Models, Animal[MESH]|Drug Delivery Systems/methods[MESH]|Female[MESH]|Lung Neoplasms/blood supply/*drug therapy/metabolism[MESH]|Mammary Neoplasms, Experimental/blood supply/*drug therapy/metabolism[MESH]|Mice[MESH]|Neovascularization, Pathologic/drug therapy/prevention & control[MESH]|Vascular Endothelial Growth Factors/*antagonists & inhibitors/metabolism[MESH] |
