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Mechanisms of centrosome separation and bipolar spindle assembly Tanenbaum ME; Medema RHDev Cell 2010[Dec]; 19 (6): 797-806Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.|Animals[MESH]|Biomechanical Phenomena[MESH]|Cell Division/*physiology[MESH]|Centrosome/*physiology[MESH]|Humans[MESH]|Kinesins/physiology[MESH]|Kinetochores/physiology[MESH]|Microtubules/physiology[MESH]|Models, Biological[MESH]|Molecular Motor Proteins/physiology[MESH]|Nuclear Envelope/physiology[MESH]|Prophase/physiology[MESH]|Spindle Apparatus/*physiology[MESH] |
