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Lithium nephrotoxicity Oliveira JL; Silva Junior GB; Abreu KL; Rocha Nde A; Franco LF; Araujo SM; Daher Ede FRev Assoc Med Bras (1992) 2010[Sep]; 56 (5): 600-6Lithium has been widely used in the treatment of bipolar disorder. Its renal toxicity includes impaired urinary concentrating ability and natriuresis, renal tubular acidosis, tubulointerstitial nephritis progressing to chronic kidney disease and hypercalcemia. The most common adverse effect is nephrogenic diabetes insipidus, which affects 20-40% of patients within weeks of lithium initiation. Chronic nephropathy correlates with duration of lithium therapy. Early detection of renal dysfunction should be achieved by rigorous monitoring of patients and close collaboration between psychiatrists and nephrologists. Recent experimental and clinical studies begin to clarify the mechanisms by which lithium induces changes in renal function. The aim of this study was to review the pathogenesis, clinical presentation, histopathological aspects and treatment of lithium-induced nephrotoxicity.|*Kidney Diseases/chemically induced/diagnosis/drug therapy[MESH]|Antipsychotic Agents/adverse effects[MESH]|Bipolar Disorder/drug therapy[MESH]|Humans[MESH]|Lithium/*adverse effects[MESH] |
