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p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells Mak ASCell Adh Migr 2011[Mar]; 5 (2): 144-9The p53 transcription factor, discovered in 1979 ( 1;2) , is well known as a potent suppressor of tumor development by inhibiting cell cycle progression, and promoting senescence or apoptosis, when the genome is compromised or under oncogenic stress ( 3) . Accumulating evidence has pointed to an alternative role of p53 in the curtailment of tumor progression and colonization of secondary sites by negatively regulating tumor cell metastasis ( 4;5) . Recently, we have found that p53 suppresses Src-induced formation of podosomes and associated invasive phenotypes in fibroblasts and vascular smooth muscle cells (VSMC) ( 6;7) . In this review, I will focus on some recent studies that have identified p53 as a suppressor of cell migration and invasion in general, and VSMC podosome formation and ECM degradation in particular.|Actins/genetics/metabolism[MESH]|Animals[MESH]|Apoptosis[MESH]|Calmodulin-Binding Proteins/genetics/*metabolism[MESH]|Cell Communication[MESH]|Cell Movement[MESH]|Cortactin/genetics/metabolism[MESH]|Cytoskeleton/physiology[MESH]|Extracellular Matrix/metabolism/pathology[MESH]|Fibroblasts/cytology/metabolism[MESH]|Gene Expression Regulation[MESH]|Genes, p53[MESH]|Genes, src[MESH]|Humans[MESH]|Mice[MESH]|Muscle, Smooth, Vascular/cytology/metabolism[MESH]|PTEN Phosphohydrolase/genetics/metabolism[MESH]|Phosphorylation[MESH]|Rats[MESH]|Rosette Formation[MESH]|STAT3 Transcription Factor/genetics/metabolism[MESH]|Signal Transduction[MESH]|Tumor Suppressor Protein p53/genetics/*metabolism[MESH] |
