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Aplastic anemia: first-line treatment by immunosuppression and sibling marrow transplantation Passweg JR; Marsh JCHematology Am Soc Hematol Educ Program 2010[]; 2010 (�): 36-42Newly diagnosed aplastic anemia is a serious condition, with more than 75% (higher in young patients) becoming long-term survivors if diagnosed and treated appropriately. First-line treatment approaches include immunosuppressive treatment using the combination of antithymocyte globulin and cyclosporine A for patients without a sibling donor and HLA identical sibling transplant for patients younger than age 40 with a donor. Best transplant strategies have been defined and include conditioning with cyclophosphamide and antithymocyte globulin, marrow as a stem cell source, and graft-versus-host diease prophylaxis using cyclosporine A and methotrexate. It is against these standard treatment approaches that any therapeutic progress has to be measured.|*Bone Marrow Transplantation[MESH]|*Immunosuppression Therapy[MESH]|*Siblings[MESH]|Anemia, Aplastic/*therapy[MESH]|HLA Antigens/immunology[MESH]|Humans[MESH]|Tissue Donors[MESH] |