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Vascular and metabolic properties of manidipine Buset Rios N; Rodriguez Esparragon F; Fernandez-Andrade Rodriguez C; Rodriguez Perez JCNefrologia 2011[]; 31 (3): 268-74The combination of renin-angiotensin system blockers with calcium channel blockers appears to be one of the most effective options for treating hypertension and diabetes.Nevertheless, not all calcium blockers behave in the same manner. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. In addition,T-type channels are related to proliferation, inflammation,fibrosis, vasoconstriction and activation of the renin-angiotensin system. The inhibition of these factors could explain the non-haemodynamic effects of manidipine as compared to other blockers.|*Insulin Resistance[MESH]|Albuminuria/*drug therapy[MESH]|Calcium Channel Blockers/*metabolism/*pharmacology[MESH]|Cardiovascular Diseases[MESH]|Dihydropyridines/*pharmacology[MESH]|Humans[MESH]|Nitrobenzenes[MESH]|Oxidative Stress/*drug effects[MESH]|Piperazines[MESH] |
