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Ventricular tachyarrhythmias (out-of-hospital cardiac arrests) Lang ES; Browning KBMJ Clin Evid 2010[Dec]; 2010 (ä): äINTRODUCTION: Pulseless ventricular tachycardia and ventricular fibrillation are the main causes of sudden cardiac death, but other ventricular tachyarrhythmias can occur without haemodynamic compromise. Ventricular arrhythmias occur mainly as a result of myocardial ischaemia or cardiomyopathies, so risk factors are those of cardiovascular disease. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of electrical therapies for out-of-hospital cardiac arrest associated with ventricular tachycardia or ventricular fibrillation? What are the effects of antiarrhythmic drug treatments for use in out-of-hospital cardiac arrest associated with shock-resistant ventricular tachycardia or ventricular fibrillation? What are the effects of treatments for comatose survivors of out-of-hospital cardiac arrest associated with ventricular tachycardia or ventricular fibrillation? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 15 systematic reviews and RCTs that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: amiodarone, bretylium, defibrillation, lidocaine, procainamide, and therapeutic hypothermia.|*Electric Countershock[MESH]|*Out-of-Hospital Cardiac Arrest[MESH]|Amiodarone[MESH]|Death, Sudden, Cardiac[MESH]|Humans[MESH]|Hypothermia, Induced[MESH]|Lidocaine[MESH]|Ventricular Fibrillation/therapy[MESH] |
