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Immune suppression in head and neck cancers: a review Duray A; Demoulin S; Hubert P; Delvenne P; Saussez SClin Dev Immunol 2010[]; 2010 (ä): 701657Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis.|*Tumor Escape[MESH]|Animals[MESH]|Apoptosis[MESH]|Carcinoma, Squamous Cell/epidemiology/*immunology/physiopathology[MESH]|HLA Antigens/genetics/metabolism[MESH]|Head and Neck Neoplasms/epidemiology/*immunology/physiopathology[MESH]|Humans[MESH]|Immunosuppression Therapy[MESH]|Macrophages/immunology[MESH]|Neovascularization, Pathologic[MESH]|T-Lymphocytes/immunology[MESH]|Vascular Endothelial Growth Factor A/metabolism[MESH] |
