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Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless Frank-Starling Gain index Bollensdorff C; Lookin O; Kohl PPflugers Arch 2011[Jul]; 462 (1): 39-48This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.|Animals[MESH]|Models, Cardiovascular[MESH]|Myocardial Contraction/*physiology[MESH]|Myocytes, Cardiac/cytology/*physiology[MESH]|Stress, Mechanical[MESH] |