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A critical evaluation of the role of aromatase inhibitors as adjuvant therapy for postmenopausal women with breast cancer Petit T; Dufour P; Tannock IEndocr Relat Cancer 2011[Jun]; 18 (3): R79-89The introduction of aromatase inhibitors (AI) has provided more options for adjuvant treatment of postmenopausal women; they are associated with improved disease-free survival, but less commonly with improvements in overall survival. Current evidence suggests that women at high risk of recurrence, especially those with node-positive disease, should receive an AI for 2 years as part of their treatment, but routine prescription of AIs to postmenopausal patients with low-risk disease is not appropriate. Not only the expected benefits but also the specific toxicity of the prescribed hormone therapy, and its cost, should be considered when selecting treatment.|*Postmenopause/drug effects[MESH]|Antineoplastic Agents, Hormonal/administration & dosage/therapeutic use[MESH]|Aromatase Inhibitors/administration & dosage/*therapeutic use[MESH]|Breast Neoplasms/*drug therapy/mortality[MESH]|Carcinoma/*drug therapy/mortality[MESH]|Chemotherapy, Adjuvant[MESH]|Female[MESH]|Humans[MESH]|Randomized Controlled Trials as Topic[MESH] |
