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Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes Yu EA; Weaver DRAging (Albany NY) 2011[May]; 3 (5): 479-93The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.|Aging/*genetics/physiology[MESH]|Circadian Clocks/*genetics[MESH]|Circadian Rhythm/*physiology[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Light[MESH]|Neoplasms/*genetics[MESH]|Periodicity[MESH]|Phenotype[MESH]|Trans-Activators/physiology[MESH] |
