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A meta-analysis of low-dose aspirin for prevention of preeclampsia Trivedi NAJ Postgrad Med 2011[Apr]; 57 (2): 91-5BACKGROUND: Low-dose aspirin (LDA) is widely used for prevention of preeclampsia. However, conflicting results have been obtained from various studies. AIM: The aim of our study was to evaluate the effect of LDA in prevention of preeclampsia in high-risk and low-risk women. MATERIALS AND METHODS: A total of 19 randomized control trials were identified using PUBMED search engine and Cochrane Clinical Trial register. The study population was divided into high-risk and low-risk groups. The effect measured was incidence of preeclampsia in women taking either LDA or placebo where the relative risk (RR) and the 95% confidence interval (CI) were calculated for both groups. RESULTS: A total of 28237 women were studied, out of which 16550 were in the low-risk group while 11687 were in the high-risk group. The overall incidence of preeclampsia was 7.4%. With the aspirin group it was 6.9% while in the placebo group it was 7.8%. In the high-risk group there was 21% reduction in the risk of preeclampsia associated with the use of aspirin (RR 0.79, 95% CI 0.65-0.97). However, LDA is not effective in reducing the risk in low-risk population (RR 0.86, 95% CI 0.64-1.17). CONCLUSION: LDA has a small effect in the prevention of preeclampsia in women considered to be at high risk for the disease. However, it is not effective in reducing the risk in the low-risk group.|Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use[MESH]|Aspirin/administration & dosage/*therapeutic use[MESH]|Dose-Response Relationship, Drug[MESH]|Female[MESH]|Humans[MESH]|Pre-Eclampsia/*prevention & control[MESH]|Pregnancy[MESH]|Risk[MESH] |
