Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2 Brittain JM; Wang Y; Wilson SM; Khanna RChannels (Austin) 2012[Mar]; 6 (2): 94-102A recent study identified Nipsnap1 as an auxiliary protein inhibiting TRPV6 ion channel activity. Based upon this finding, we investigated the role of Nipsnap1, and the closely related Nipsnap2, in Ca(2+) channel regulation. Here, we find that overexpression of Nipsnap2 caused a 45% increase in currents though L-type Ca(2+) channels in a neuronal cell line, while siRNA knockdown of Nipsnap2 greatly reduced L-type currents. The increased influx through L-type Ca(2+) channels due to Nipsnap2 overexpression led to increased phosphorylation of the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) along with enhanced expression of several transcription factors and CREB target genes. These experiments highlight a novel role of Nipsnap2 in transcriptional regulation via L-type Ca(2+) channels.|*Calcium Signaling[MESH]|*Transcription, Genetic[MESH]|Animals[MESH]|Calcium Channels, L-Type/*physiology[MESH]|Calcium/metabolism[MESH]|Cell Line, Tumor[MESH]|Cyclic AMP Response Element-Binding Protein/*metabolism[MESH]|Gene Expression Regulation[MESH]|Mice[MESH]|Mitochondrial Proteins/physiology[MESH]|Nerve Tissue Proteins/metabolism/*physiology[MESH]|Neurons/*metabolism/physiology[MESH]|Patch-Clamp Techniques[MESH]|Phosphorylation[MESH]|RNA, Small Interfering[MESH]|Rats[MESH] |
