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Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?Fichna J; Mokrowiecka A; Cygankiewicz AI; Zakrzewski PK; Malecka-Panas E; Janecka A; Krajewska WM; Storr MANeurogastroenterol Motil 2012[Nov]; 24 (11): e557-60Recent reports suggested that the activation of Transient Receptor Potential Vanilloid 4 (TRPV4) receptors in the gastrointestinal tract has pro-inflammatory effects. In this study, we demonstrated for the first time that TRPV4 mRNA expression is up-regulated in patients with inflammatory bowel diseases (IBD). Furthermore, selective blockade of TRPV4 in the 2,4,6-trinitrobenzenesulfonic acid animal model alleviates colitis and pain associated with the intestinal inflammation. Our study indicates that TRPV4 may play a role in mechanisms of defense in intestinal inflammation and that TRPV4 may be an attractive target for future systemic or topic anti-inflammatory treatment in patients with IBD.|Animals[MESH]|Disease Models, Animal[MESH]|Gastrointestinal Agents/pharmacology[MESH]|Humans[MESH]|Inflammatory Bowel Diseases/complications/*metabolism[MESH]|Mice[MESH]|Pain/etiology/*metabolism[MESH]|Real-Time Polymerase Chain Reaction[MESH]|Reverse Transcriptase Polymerase Chain Reaction[MESH]|Sulfonamides/pharmacology[MESH]|TRPV Cation Channels/antagonists & inhibitors/*metabolism[MESH] |
