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Understanding the rhythm of breathing: so near, yet so far Feldman JL; Del Negro CA; Gray PAAnnu Rev Physiol 2013[]; 75 (ä): 423-52Breathing is an essential behavior that presents a unique opportunity to understand how the nervous system functions normally, how it balances inherent robustness with a highly regulated lability, how it adapts to both rapidly and slowly changing conditions, and how particular dysfunctions result in disease. We focus on recent advancements related to two essential sites for respiratory rhythmogenesis: (a) the preBotzinger Complex (preBotC) as the site for the generation of inspiratory rhythm and (b) the retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG) as the site for the generation of active expiration.|*Respiration[MESH]|*Respiratory Physiological Phenomena[MESH]|Animals[MESH]|Exhalation/physiology[MESH]|Humans[MESH]|Inhalation/physiology[MESH]|Medulla Oblongata/physiology[MESH]|Periodicity[MESH]|Respiratory Mechanics/*physiology[MESH]|Respiratory System/*innervation[MESH] |
