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Lipoxygenase: an emerging target for stroke therapy van Leyen KCNS Neurol Disord Drug Targets 2013[Mar]; 12 (2): 191-9Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review.|Animals[MESH]|Arachidonic Acid/metabolism[MESH]|Enzyme Inhibitors/*therapeutic use[MESH]|Humans[MESH]|Lipoxygenase/*metabolism[MESH]|Models, Biological[MESH]|Stroke/*drug therapy/*enzymology/pathology[MESH] |
